Abstract
Here, we report a case of effective treatment of an intractable systemic lupus erythematosus (SLE) using mycofenol mofetil and tacrolimus. In this case, the SLE activity was resistant to single immunosuppressive drug therapy such as azathioprin, tacrolimus, cyclosporin A, mycofenol mofetil and prednisolone. Moreover, although she was also treated with 5courses of corticosteroid pulse therapy, double membrane filtration plasmapheresis, and plasma exchange, none of these were effective. After informed consent, treatment using a combination of mycofenol mofetil and tacrolimus together with prednisolone was started. After two months, proteinuria, edema, hypocomplementemia, and alopecia were improved. Thus, the combination therapy including mycofenol mofetil and tacrolimus should be considered as a treatment for SLE, if it is intractable to standard treatment.
