Clinical Rheumatology and Related Research
Online ISSN : 2189-0595
Print ISSN : 0914-8760
ISSN-L : 0914-8760
original article
Successful treatment of a refractory case of systemic lupus erythematosus with tacrolimus and mycophenolate mofetil
Tomoki ItoYoshio OzakiAkihiro TanakaKeiko ShimamotoHideki AmuroKatsuyuki KawakamiYonsu SonShosaku Nomura
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JOURNAL FREE ACCESS

2010 Volume 22 Issue 3 Pages 298-304

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Abstract
    Here, we report a case of effective treatment of an intractable systemic lupus erythematosus (SLE) using mycofenol mofetil and tacrolimus. In this case, the SLE activity was resistant to single immunosuppressive drug therapy such as azathioprin, tacrolimus, cyclosporin A, mycofenol mofetil and prednisolone. Moreover, although she was also treated with 5courses of corticosteroid pulse therapy, double membrane filtration plasmapheresis, and plasma exchange, none of these were effective. After informed consent, treatment using a combination of mycofenol mofetil and tacrolimus together with prednisolone was started. After two months, proteinuria, edema, hypocomplementemia, and alopecia were improved. Thus, the combination therapy including mycofenol mofetil and tacrolimus should be considered as a treatment for SLE, if it is intractable to standard treatment.
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© 2010 The Japanese Society for Clinical Rheumatology and Related Research
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