Abstract
The effective period of antibiotic prophylaxis on postoperative infectious complications was evaluated in our centre on 135 patients undergoing total knee replacement. Of 135 patients, 45 received CEZ or CMZ over 48 hours(1 g at induction of anesthesia and 1 g every 12 h,d.i.v.), 90 patients did MINO for oral administration at least for 14 days after drip administering of cefem over 48 hours as shown in ahead.
There was no significant difference in the rate of patients who developed superficial surgical site infection between these two groups (one patient in the former and two patients in the later group). CRP and WBC were evaluated in these two groups and the level of CRP was higher at 1 week after surgery in the later group. The difference in the two groups was not significant in the occurrence of proven or suspected infections involving other body systems. Preoperative HbA1c did not show correlation statistically with the occurrence of SSI nor infections involving other body systems―, even though the level of WBC at 1,2 weeks after surgery and CRP at 1 week was significantly higher in the group with more than 6.4 of HbA1c.
