Abstract
It is estimated that there are about 100 hundred children with Juvenile-onset fibromyalgia (JFM), that accounts for 2. 5-5.0% of all patients having fibromyalgia including adults in Japan. The condition is characterized by widespread musculoskeletal pain and other associated symptoms, including fatigue, nonrestorative sleep,headaches, irritable bowel symptoms, dysautonomia and mood disorders such as anxiety and/or depression. JFM is diagnosed on the combination of disease history, physical examination to determine the 18 tender points and allodynia, pain from gently touching their hair, and negative results of blood tests. Recent studies have reveled that genetic influences, biologic factors,and environment are associated with the“Central Sensitization”.
This Review focuses on our current knowledge of the condition, provides an update of the latest research advances, and highlights areas for further study.
