Influence of intraarticular injection with triamcinolone for rheumatoid arthritis patient

Abstract

［Object］

The effect of intraarticular injection with triamcinolone（TCN）for rheumatoid arthritis（RA）patient was reviewed retrospectively, and evaluated statistically.

［Methods］

RA patients who were injected intraarticularly with TCN from April 2014 to March 2019 were picked up. Their clinical parameters were compared before and after injection with a paired T-test. Patients were classified according to number of injections. Changes in clinical parameters including bone mineral density（BMD）were compared between pairs of the groups with ANOVA.

［Results］

Injections were performed 1020 times for 208 patients including 45 males and 163 females with 67.1 as the mean age. All components of the simplified disease activity index and pain score with visual analog scale decreased significantly within within 1%, but there was no significant decrease at any time in the modified Health Assessment Questionnaire, This tendency was also demonstrated at one year after injection. There was no significant difference of clinical parameters between any pair of the groups when classified by frequency of injection, while prevalence of adverse events tended to occur more in groups with more injections compared to groups with fewer injection, but without statistical significance.

［Conclusions］

Intraarticular injection is useful for disease activity and pain control, and improvement of activity in daily living. There remains some debate about effect determined by frequency of injection.