Anti-transcriptional intermediary factor1-γ（TIF1-γ）antibody-positive dermatomyositis with triple breast cancers

Abstract

Dermatomyositis（DM）is an autoimmune disease characterized by inflammation of the muscle, specific skin lesion, and autoantibody positivity. Each DM-associated autoantibody isiesare associated with clinical phenotype. Anti–transcriptional intermediary factor 1-γ（TIF1-γ）autoantibodyies has ve been described in adult DM and DM patients with anti-TIF1-γ antibody had a higher proportion of malignancy.

We herein report the case of a 71-year-old Japanese woman with DM with anti-TIF1-γ antibody who had triple breast cancer. After cancer resection, she was treated with prednisolone, intravenous immune globulin. Breast cancer did not relapse and her TIF1-γ has been negative for 3 years. Our case suggests that measuring anti-TIF1-γ antibody regularly may be important for the prognosis.