2022 Volume 34 Issue 2 Pages 118-127
Objectives: To identify risk factors associated with renal dysfunction and difference between serum cystatin C（Cys-eGFR）and creatine（Cr-eGFR）in estimating glomerular filtration rate in patients with rheumatoid arthritis（RA）. Methods: 359 patients with RA were enrolled in this study. The risk factor associated with renal dysfunction was analyzed using Cys-eGFR for one year. The difference between levels of Cys-eGFR and Cr-eGFR at baseline was used for analysis.
Results: The risk factor associated with the deterioration of renal dysfunction was disease activity（odds ratio, 1.76; 95% confidence interval, 1.05-2.96）in patients under 60 years old. When comparing levels of Cys-eGFR and Cr-eGFR, Cr-eGFR was significantly greater in patients 80 and older years old（P = 0.034）and significantly lower in patients under 60 years old（P < 0.001）.
Conclusions: In RA patients under 60 years, it is important to control the disease activity for preventing the renal dysfunction. Use of Cys-eGFR might be more appropriate for the management of renal function in elderly patients with RA.
