Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
An anti-tumorigenic role of the Warburg effect at emergence of transformed cells
Kojiro IshibashiRiku EgamiKazuki NakaiShunsuke Kon
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JOURNALS FREE ACCESS Advance online publication

Article ID: 18018


The Warburg effect is one of the hallmarks of cancer cells, characterized by enhanced aerobic glycolysis. Despite intense research efforts, its functional relevance or biological significance to facilitate tumor progression is still debatable. Hence the question persists when and how the Warburg effect contributes to carcinogenesis. Especially, the role of metabolic changes at a very early stage of tumorigenesis has received relatively little attention, and how aerobic glycolysis impacts tumor incidence remains largely unknown. Here we discuss a novel paradigm for the effect of the Warburg effect that provides a suppressive role in oncogenesis.
Keywords: Warburg effect, aerobic glycolysis, cell competition, EDAC

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© 2018 The Author(s) CC-BY 4.0 (Submission before October 2016: Copyright © Japan Society for Cell Biology)
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