Extracellular Products of Staphylococcus aureus Reversibly Inhibit the Terminal Differentiation of Cultured Mouse Epidermal Cells
1987 年 12 巻 4 号 p. 395-399
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1987 年 12 巻 4 号 p. 395-399
The effect of extracellular products from Staphylococcus aureuson the differentiation of mouse epidermal cells was studied using an in vitro cell culture system. The extracellular products from a clinical strain of S. aureus isolated from human skin lesions reversibly inhibited the Ca++-induced terminal differentiation of epidermal cells, as determined by their morphology and the extent of cornified envelope formation. This suggests that a similar modification of cell differentiation is involved in the pathogenesis of S. aureus-induced skin disease.
