抄録
Bredinin, a new cytotoxic antibiotic, induced chromosome aberrations and sister chromatid exchanges in L5178Y cells. The respective maximum sensitivity occurred about the late S and middle S phases of the cell cycle. Bredinin enhanced sister chromatid exchanges when added to ethylmethanesulfonate, but caffeine had little effect. The sister chromatid exchanges induced by bredinin are discussed in relation to formation of chromosome aberrations.
