Cytological Studies of Tumors, XXIII

Comparison of the chromosomes between the Yoshida sarcoma and its single-cell clone

Abstract

The present study deals with a comparison of the chromosomes between the Yoshida sarcoma subline A and its single-cell clone. It was found that the single-cell clone here established and the original tumor were similar in their chromosome pattern. The cytological similarity between the single-cell clone and the original tumor may be attributable to the facts that the neoplastic population of the Yoshida sarcoma subline A is characterized by stemline cells of a certain genotypic constitution, and that the original tumor and its single-cell clone are genotypically as well as chromosomally identical, since they have originated from the stem-cells of a similar genotype.
The authors wish to express their sincere thanks to Professor S. Makino for his kind direction and improvement of this manuscript for publication. Further cordial thanks are offered to Mr. T. Tanaka and Mrs. K. Kanô for their valuable advices and technical guidance.