Replication in the Marker Chromosomes of a Hypertriploid Mouse Ascites Tumour

抄録

We have studied the replication in the marker chromosomes of a hypertriploid mouse ascites tumour.
Tritiated thymidine has been used, followed by the autoradiographic process, to determine the marked portions ofthe chromosomes in the later replication periods and time during which the chromosomes are synthesizing complementary DNA.
The metacentric chromosome terminates replication in the terminal and proximal regions of the arms. There is no ordered sequence in the DNA replication in this chromosome.
Two minute chromosomes replicate the complementary DNA early and syn-chronically, and the third replicates later. The intensity of silver gains differs in these 3 chromosomes, at a determinate experimental hour when all our marked.
The maximum number of marked chromosomes, and the maximum intensity of silver grains per chromosome appears during the early replication periods.