Ultrastructural Changes in Cellular Components in WI Cells Inoculated with Adenovirus Type 5

Abstract

In the WI cells after 44 hours inoculation with adenovirus type 5 (Ad-5), there were many intranuclear viral particles and dense patches. Frequently, large nonviral paracrystalline bodies from 2 to 3μ in diameter were in the nuclei. In the cytoplasm of the inoculated cells, many of the mitochondria were disorganized by vacuolization. Sometimes a dense granular material was present in the mitochondria. Bleblike swelling of rough surfaced endoplasmic reticulum (ER) and partial fusion of cisternal membranes formed a network of ER cisternae.