Abstract
G banded karyotypic analysis of normal parents, whose second child was stillborn with multiple congenital abnormalities, revealed a normal 46, XY father and 45, XX, t (13q; 14q) mother. By a simplified silver staining technique it was possible to demonstrate that the entire secondary constriction of both chromosomes were lost in the process of translocation. C banding displayed the translocated chromosome to be monocentric. We therefore conclude that the translocation represents a typical Robertsonian fusion. Loss of two nucleolar organizers has seemingly no deleterious effect in development.
