Abstract
In the present study an endeavour has been made to assay the mutagenicity of an organophosphorus pesticide, monocrotophos (Nuvacron) in mouse cytogenetic test system. Cytogenetic assays like somatic chromosome aberration, micronucleus test and sperm shape abnormalities have been done. Different doses (5, 2.5 and 1.25 mg/kg), different exposure times (6, 24, 48 and 120 hours) and different routes (i.p., p.o. and sc) of administration have been employed. The effects are mostly dose, time and route dependent. Comparision of acute and chronic treatments revealed that the chemical has no cumulative effect. Relative sensitivity of cytogenetic assays has been found to be as sperm shape abnormality>chromosome aberration>micronucleus. Monocrotophos has been found to be mutagenic in the present test system.
