6-Thioguanine (6 TG) Resistant Mutation, Chromosomal Aberrations and Sister Chromatid Exchanges (SCE's) in V 79 Cells

III. Concluding remarks

Abstract

The widely accepted assays (HGPRT gene locus mutation, chromosomal aberrations and sister chromatid exchanges) for the evaluation of genotoxicity of environmental chemicals in mammalian cell systems, were comparatively studied due to Safrole and ICR-170 treatments to know the interrelationship between them. The correlation co-efficient between mutation frequency-chromosomal aberrations and mutation frequency-SCE's due to Safrole was insignificant contrary to ICR-170 treatment. Thus it is deduced that the correlation between these biological end points may be positive or negative depending upon the natare of physical or chemical agents.