抄録
A transplantable mouse model, each cell of which has a marker chromosome (Bj chromosome) was used in this experiment to determine whether maternal cells can migrate transplacentally to enter fetal circulation, the cell transplacental permeability at different embryonic development stages and a possibility of direct leukemia infection from mother to son (daughter). Our results indicate that during pregnancy the cell permeability of placenta depends on the embryonic development stage, e.g., very high cell permeability (100%) in an early- and mid-gestations of pregnancy and extremely low (4.5%) in the later stage. We also report here that maternal leukemia cells can transfer into the fetus transplacetally during pregnancy, leading to a direct infection of leukemia from mother to her offspring. Both the early- and mid-term gestations are more dangerous periods for the maternal leukemia cell infection.
