Effect of Lead Acetate on Male Germinal Cells of Swiss Mice

抄録

The toxicity of lead acetate in the male germ cells of Swiss mice has been studied. A single intraperitoneal dose of lead acetate (50 mg/kg body weight) not only caused testicular atrophy but also affected the normal sperm count to decline significantly with the production of a significantly increased amount of morphologically abnormal sperm in the treated animals. Further, a marked decrease both in the body and testes weight in the lead injected animals associated with a significant decrease in the ascorbic acid content in the testicular tissue have been observed.