Cell-functional analysis for epithelial ovarian cancer: microsatellite instability

Abstract

Recent studies have revealed that microsatellite instability due to deficiency of DNA mismatch repair systems could be correlated to both hereditary and sporadic cancer, and involve a mechanism of acquired resistance to anti neoplastic agents. We report the current understanding of the correlation between DNA mismatch repair functions and resistance to platinum agents in epithelial ovarian cancer based on our previous report using chromosome transfer, microsatellite assay for surgically resected specimens, and a review of the English literature.