Abstract
In cancer immunotherapy with dendritic cells(DCs), which are the most potent antigen-presenting cells, it is important that DCs present peptides derived from tumor-associated antigens on major histocompatibility complex(MHC) class I molecules and activate tumor-specific cytotoxic T lymphocytes. However, exogenous antigens are generally presented on MHC class II but not class I molecules. To induce the effective immunotherapy for cancer, it is necessary that the antigen delivery carrier which can induce MHC class I presentation of exogenous antigens is developed.
Several strategies to induce DCs to present exogenous antigens on MHC class I have been reported. First, DCs that phagocytosed a particulate form of antigens present peptides derived from the antigens on MHC class I. Second, DCs that incorporated antigens via certain endocytic receptors such as Fcγ receptors efficiently present peptides on MHC class I. Thus, we combined these two strategies and prepared the antigen-containing IgG-conjugated liposomes(IgG liposomes). In this review, we introduced about the feasibility of IgG liposomes as the antigen delivery carrier in cancer immunotherapy with DCs.
