Development of tumor vaccine therapy using γ-PGA nanoparticles as an antigen delivery carrier

Abstract

Establishment of the technique capable of delivering tumor-associated antigen(TAA) to antigen-presenting cells efficiently is expected to improve efficacy of tumor vaccine therapy. We succeeded in augmentation of tumor immunity based on efficient induction of the cytotoxic T cells specific for TAA by applying poly(γ-glutamic acid)-based nanoparticles (γ-PGA NPs) as antigen delivery carriers. In this review, we give an outline about a utility of nanoparticle DDS technology in tumor vaccine therapy, mainly on our data using γ-PGA NPs.