Abstract
Drug particles used for dry powder inhalation (DPI) are required to have good flowability in handling and dispersibility in delivering the drug into lung in order to effectively treat the pulmonary and systemic diseases. In this study, design of drug particles for DPI by using a supercritical carbon dioxide (SC-CO2) has been presented. First of all, micronization process of water insoluble drug by a SC-CO2 and its improved drug dissolution property were shown. Secondly, a novel agglomeration method of micronized drug, so called "Freeze Granulation by Supercritical Fluid:FG-SCF" has been developed and its application to DPI was discussed.
