Pulmonary delivery by novel sea-urchin like microparticles

Abstract

Recent progress of micronization technique has greatly contributed to the development of several functional medicines based on the arrangement of their shape in μ∼nm order. For optimized inhalable dry powders, their aerodynamic particle diameters should be 1∼5 μm to achieve effective pulmonary delivery, while micronization process may generates stronger cohesive force between them, thereby leading to lower dispersion. To overcome these problems, hollow porous microparticles with low density have been developed.
In this topic, we review the development of hollow porous microparticles for inhalable dry powder formulation, and introduce novel sea-urchin like microparticles that we have developed.