Abstract
Transcutaneous immunization (TCI) system utilizing skin immune function is a promising needle-free, easy-to-use, and non-invasive vaccination method instead of conventional injectable vaccination method. For effective TCI system, it is essential to establish the fundamental techniques that antigenic proteins were delivered to antigen-presenting cells in the epidermal layer.
In this review, we give outline of recent research trend about antigenic protein delivery techniques for TCI and introduce our basic and preclinical research about TCI using our original hydrogel patch formulation containing antigenic proteins.
