Regulation of pharmacokinetics for low molecular weight drugs

Abstract

As for the nuclear medicine diagnostics, not only follow-up of a usual diagnosis and the therapeutic gain but also applications to the early diagnostics and the treatment effect forecast are possible as the in-vivo imaging for biological function. Additionally, the nuclear medicine imaging can visually verify the in-vivo effect of the regulation of pharmacokinetics since it can pursue dynamic distribution of radiopharmaceuticals in human whole body. In this paper, the current state of the early diagnostics and the therapy evaluation based on a molecular imaging strategy and the applications to the drug distribution monitor are outlined.
Moreover, it introduces radiopharmaceuticals as model drugs with novel pharmacokinetics regulation for low molecular weight drugs.