The possibility of antigenic peptide, protein and DNA delivery by percutaneous vaccination

Abstract

Skin is a leading candidate tissue in delivery system of peptide and protein including T-cell epitope sequence, and T-cell epitope-coding DNA because the dendritic cells which function as a powerful antigen-presenting cell for tumor- and pathogenic microorganism-specific T cell activation resides in epidermis and dermis of the skin. In this article, we describe the current topics of percutaneous vaccination for immunogenic antigen delivery.