Drug delivery into the tumor vasculature with the cell-internalizing monoclonal antibody

Abstract

Monoclonal antibodies (mAbs) that are internalized into cells are a current focus in the development of DDS-based drugs such as antibody-drug conjugates (ADCs). The discovery of potent cell-internalizing mAbs, however, requires labor-intensive screening of a massive number of candidates. Here we describe a phage display-based high-throughput screening system to rapidly isolate cell-internalizing mAbs, then also discuss about the efficacy of tumor vascular targeting with cell-internalizing mAbs which target tumor endothelial cells.