siRNA delivery systems for skin disorders treatment

Abstract

In recent years, there is a growing need for nucleic acid medicines targeting intractable skin diseases such as atopic dermatitis. Human skin is an available organ with the largest surface area for noninvasive drug administration. However, the intradermal permeability of hydrophilic and high molecular weight substances such as siRNA is strongly limited by the barrier function of the skin. Here, we introduce the siRNA delivery researches for skin disease treatment.