2018 Volume 33 Issue 4 Pages 293-302
Seborrheic keratosis is characterized as sharply demarcated brownish plaques with verrucous surfaces. This lesion is considered unattractive and disfiguring and may have negative psychological impacts. Thus, they are often removed for cosmetic reasons by surgical treatments, such as cryotherapy and laser surgery. However, these treatments require regular outpatient treatments for complete removal of the lesions, incurring high costs. Drug therapy for seborrheic keratosis is an attractive treatment option for self-treatment at home but is not well established, because skin permeability of candidate ingredients for seborrheic keratosis is relatively low by keratinaization of stratum corneum. In this review, we introduce the development of a novel drug therapy using a self-dissolving microneedle patch which can directly deliver candidate ingredients to the epidermis by puncturing the stratum corneum.
