Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
[Feature articles] “Precise design and structural control of polymer materials for DDS” Editor:Atsushi Maruyama
Design of VEGF Releasing Fiber Mat for Effective Transplantation of Cardiomyocyte Sheets
Kenichi NagaseHideko Kanazawa
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2019 Volume 34 Issue 3 Pages 173-178

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Abstract
Recently, cell transplantation therapy using cellular tissue has been used as an effective therapy for patient. In order to improve the efficacy of the cellular tissue transplantation, vascular endothelial growth factor (VEGF) releasing fiber mat was developed. Using the fiber mat, six layered cardiomyocyte sheets can be transplanted at once, because the local release of VEGF induced the vascularization into the transplanted stacked cardiomyocyte sheets. In this article, the design strategy of the VEGF releasing fiber mat was introduced with the background of cellular tissue transplantation.
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© 2019 The Japan Society of Drug Delivery System
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