Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
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Volume 34, Issue 3
Precise design and structural control of polymer materials for DDS
Displaying 1-12 of 12 articles from this issue
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[Feature articles] “Precise design and structural control of polymer materials for DDS” Editor:Atsushi Maruyama
  • [FOREWORD]Precise design and structural control of polymer materials for DDS
    Atsushi Maruyama
    2019 Volume 34 Issue 3 Pages 149
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.149
    JOURNAL FREE ACCESS
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  • [OPINION]Forward to New DDS Creation based on Understanding of our old research history
    Toshihiro Akaike
    2019 Volume 34 Issue 3 Pages 150-151
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.150
    JOURNAL FREE ACCESS
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  • Design of glyco polymer vesicles and their function as DDS nanofactories
    Tomoki Nishimura, Kazunari Akiyoshi
    2019 Volume 34 Issue 3 Pages 154-162
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.154
    JOURNAL FREE ACCESS
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    The development of drug delivery systems (DDS) that enable encapsulation of drugs, selective delivery to target tissues or organs, and release of drugs has improved therapeutic effect and reduced side effects. Although these conventional DDSs have valuable therapeutic effects, their effects are limited. Different approaches to the development of novel DDSs are hence desirable. Concepts such as DDS nanofactories are therefore attracting much attention. DDS nanofactories combine the features of nanoreactors and delivery carriers. They can produce drugs or transform toxic compounds into harmless compounds at disease sites. Here, we described the required features of DDS nanofactories and the characteristics of the molecular permeable glyco polymer vesicles and their functions as a DDS nanofactory.
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  • Design of pH-sensitive polymer-based immunity-inducing systems
    Eiji Yuba
    2019 Volume 34 Issue 3 Pages 163-172
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.163
    JOURNAL FREE ACCESS
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    For establishment of efficient cancer immunotherapy, antigen carriers that can deliver antigen to immunocompetent cells, activate these cells and induce antigen-specific cellular immunity are required. We synthesized functional polymers to induce membrane fusion in response to weakly acidic pH and modified these polymers onto antigen-loaded liposomes to develop antigen delivery systems for induction of cellular immunity efficiently. pH-sensitive polymer-modified liposomes were taken up by dendritic cells efficiently and achieved cytoplasmic delivery of antigenic proteins via membrane fusion with endosomal membrane responding to weakly acidic pH in endosomes. In addition, inclusion of adjuvant molecules and bioactive polysaccharide-based pH-sensitive polymers into antigen-loaded liposomes induced strong antitumor effects in tumor-bearing mice.
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  • Design of VEGF Releasing Fiber Mat for Effective Transplantation of Cardiomyocyte Sheets
    Kenichi Nagase, Hideko Kanazawa
    2019 Volume 34 Issue 3 Pages 173-178
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.173
    JOURNAL FREE ACCESS
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    Recently, cell transplantation therapy using cellular tissue has been used as an effective therapy for patient. In order to improve the efficacy of the cellular tissue transplantation, vascular endothelial growth factor (VEGF) releasing fiber mat was developed. Using the fiber mat, six layered cardiomyocyte sheets can be transplanted at once, because the local release of VEGF induced the vascularization into the transplanted stacked cardiomyocyte sheets. In this article, the design strategy of the VEGF releasing fiber mat was introduced with the background of cellular tissue transplantation.
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  • Smart Nanofiber Meshes for Cancer Thermo/Chemotherapy
    Eri Niiyama, Mitsuhiro Ebara
    2019 Volume 34 Issue 3 Pages 179-185
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.17
    JOURNAL FREE ACCESS
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    Polymeric nanofibers are an exciting new class of material and have attracted great attention because of their remarkable properties, such as high specific surface area, high porosity, high molecular alignment, or nanosize effects. Additionally, many different types of molecules can be easily incorporated into nanofibers to greatly expand their drug loading capacity or to provide the sustained release of the embedded drug molecules. Also, they can be easily manipulated as a macroscopic bulk matter that may create opportunities for profitable new uses as an implantable local drug delivery platform. This review article introduces four types of nanofibers; nanofibers with sustained and on-off drug release properties combined with thermo-therapy.
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  • Injectable hydrogel with Controlled Swelling Behavior in vivo
    Takamasa Sakai, Takeshi Fujiyabu
    2019 Volume 34 Issue 3 Pages 186-200
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.186
    JOURNAL FREE ACCESS
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    Hydrogels tend to swell in water. Thus, when a hydrogel is fabricated in the body, the gel is expected to swell. The swelling of the gel is required to be controlled, because it causes a change in shape, compression of surrounding tissue, and a decrease in mechanical properties. This review outlines hydrogels with controlled swelling behavior designed on the basis of Tetra-PEG gel, which is formed by the interconnection of two 4-functional polymers. The hydrogels are useful as biomaterials, and their application is expected in the near future.
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  • Characterization of nanomedicine in terms of regulatory science perspective
    Kazuo Sakurai
    2019 Volume 34 Issue 3 Pages 201-207
    Published: July 25, 2019
    Released on J-STAGE: October 25, 2019
    DOIhttps://doi.org/10.2745/dds.34.201
    JOURNAL FREE ACCESS
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    Liposomes and polymeric micelles containing a biologically active compound or polymers bearing pro-drug at their side chains can be categorized into “nanomedicines”. The size of the nanomedicines is in the range of 1-100 nm and the size is essential to induce biological efficacy such as biodistribution. Characterizing their accurate structures and properties, which is required by FDA, is important in terms of CMC. We presume that light or X-ray static scattering combined with a fractionation tool by use of gel or filed flow meet such demand.
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[Serial] Front line of DDS development in pharmaceutical industries
[Serial]Tips for your DDS research
“Young square”(mini review)
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