Abstract
Extracellular vesicles （EVs） exert producing cell-derived functions so that development of EV-based therapeutics is expected. There are a variety of immunotherapies using EVs. Main ones are vaccine therapy to induce antigen-specific immune response and anti-inflammatory therapy using EVs isolated from mesenchymal stem cells and other immunomodulatory cells. In recent years, results suggesting the possibility of immunotherapy utilizing EVs as vesicles secreted by cells and other characteristics unique to EVs have also been reported. In this article, we will introduce the current status of immunotherapy using EVs and discuss the future possibilities of EV-based immunotherapy.
