Comprehensive analysis of extracellular vesicle miRNA in urine using nanowire devices and AI, and its application to cancer detection

Abstract

Liquid biopsy is a method that is expected to be able to detect and track the cancers using blood, urine, saliva and other body fluids. The advantages of liquid biopsy are that it is extremely minimally invasive compared to tissue biopsies, and that it is easy to perform the repeated and frequent tests that are necessary for long-term tracking. Recently, extracellular vesicles （EVs） have been added to the list of biological materials to be analyzed by liquid biopsy. In this paper, we introduce the comprehensive analysis of microRNAs contained in EVs in urine using nanowire devices and AI, and its application to cancer detection.