Abstract
For the development of DDS for cancer therapy and diagnosis, it is important to visualize and evaluate the characterization and alteration of the cancer microenvironment in vivo. MRI has been widely used in clinical applications, providing high spatial resolution, excellent soft tissue contrast, and many kinds of functional imaging. MRI can provide important information for DDS development and its clinical application. In this paper, I will outline （1）in vivo imaging methods for the evaluation of the cancer microenvironment. I will also summarize trends in （2）what DDS can bring to MRI diagnosis and research, （3）MRI contrast agents and imaging methods for evaluating the tumor microenvironment, and （4）the role of MRI in addressing the challenges of DDS.
