Abstract
The use of ionic liquids as drug delivery systems has received significant attention in recent years, especially due to their ability to enhance transdermal delivery. This function is useful not only for small molecule drugs but also for biopharmaceuticals like peptides and proteins, making it a promising option for developing non-invasive transdermal drug delivery systems. However, it is crucial to ensure the safety of ionic liquids for use as drugs. To address this, we introduce ionic liquids formed from safe materials such as choline, amino acids, fatty acids, and lipids. The use of biocompatible ionic liquids has enabled the development of mid-molecular drugs or transdermal vaccines that exhibit sustained-release properties of DDS. Moreover, there are great expectations for the use of ionic liquids in new modalities such as nucleic acid medicines.
