Abstract
Fire gas poisoning is the cause of about 40％ of deaths in fire accidents. The causative gases are carbon monoxide（CO） generated by incomplete combustion of wood materials and hydrogen cyanide（HCN） generated by the combustion of household materials such as acrylics and urethane. There is no clinically available drug for these gas poisonings, and thus many people are suffered each year. The author has developed an artificial hemoglobin-model compound, hemoCD, in the organic chemistry lab. HemoCD derivatives bind gaseou components such as CO and HCN in animals during circulation and excretes these gases as in the urine. This review article describes about hemoCD-Twins, a novel drug discovery seed that enables simultaneous detoxification of CO and HCN with a single administration.
