Abstract
Inflammation is defense system regulated by immune cells, and its dysregulation is implicated in various diseases. To improve the efficacy and safety of inflammatory disease therapies, biofunctionalized polymers have been designed and their nanoparticulation technologies have been developed. In this paper, we present the design of biofunctionalized biopolymers based on polyamines and hyaluronic acid and their application to the regulation of cellular functions. These polyamine-based therapies using biofunctionalized biopolymers may serve as a novel inflammation therapy against intractable inflammatory diseases such as ulcerative colitis.
