Abstract
Polyvinylpyrrolidone（PVP） is used as an antithrombogenic polymer in artificial kidneys and other devices. We investigated the factors that affect the antithrombogenic properties of PVP and developed a new polymer that has higher antithrombogenic properties than PVP. It was found that in the case of the novel polymer, platelets are less likely to adhere when the mobility of the water around the polymer（adsorbed water） is close to that of the water around the proteins. The new polymer swells more in water than PVP, and quasielastic neutron scattering measurements indicate that the hydration constraints around the new polymer are more relaxed than PVP, resulting in larger space for movement. This polymer is applied and commercialized into medical materials such as various types of artificial kidneys, and the current status will also be introduced.
