Abstract
PI 3-kinase is known as one of the most famous lipid kinase which plays a central role in the field of growth factor-mediated signal transduction. Recent progress of molecular and developmental biology contributed to be clear numerous molecules of upstream and downstteam of PI 3-kinase. These results help us to understand the functions of PI 3-kinase and their molecular mechanisms. Furthermore, human genome draft sequence has been appeared, and several somatic mutations of the gene coding PI 3-kinase, which link to various diseases were already found. In this review, we would like to introduce the representative topics related to the PI 3-kinase pathway linking to human cancer, and current progress of our research on the relationship between malignancy of signet-ring cell carcinomas and PI 3-kinase.
