Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Toxicity of cis-platinum loaded lactic acid oligomer microspheres in mice
Tsunetoshi Sasabe, Toshio Takahashi, Akeo Hagiwara, [in Japanese], Akihiko Iwamoto, Masataka Shimotsuma, Chihiro Yoneyama, Michitoshi Itoh, Yoshihito Ikada, Shozo Muranishi
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Keywords: lactic acid oligomer microspheres, cis-platinum, acute toxicity
JOURNAL FREE ACCESS

1990 Volume 5 Issue 2 Pages 101-105

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Abstract
We evaluated the acute toxicity of a new dosage form (CDDP-ms) comprized cis-platinum loaded lactic acid oligomer micropheres following intraperitoneal administration in mice. The LD50 value of CDDP-ms was 23.8mg/kg, which was 17.6% of the LD50 value(13.5 mg/kg) of cis-platinum aqueous solution. Autopsy findings revealed no additional toxicity due to the change of the dosage form in to the microspheres.
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© Japan Society of Drug Delivery System
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