Abstract
The tissue distribution of aclarubicin(ACR)was studied and compared between the two dosage forms, namely the new dosage form (ACR-CH) and the aclarubicin aqueous solusion (ACR-sol). ACR-CH comprises 50 mg/ml of activated carbon (Mitsubisi #1500AA) and 5 mg/ml of aclarubicin in saline. Aclarubicin at 5 mg/kg was injected intrapritoneally in the form of ACR-CH or ACR-sol, and the tissues (the greater omentum, the liver, the spleen, the heart. the lung and the intracardial blood) were taken upto 7 days later. The organs and the blood was subjected to measuring aclarubicin level through the high pressure liquid chromatography(HPLC)method. The experiment showed that ACR-CH distributed higher level (2 to 10 times) of ACR concentration to the greater omentum for a long period, and lower level to the heart, the lung and intracardial blood than those of ACR-sol. These results leads to think that intraperitoneal ACR-CH distributes a large amount of ACR to the intraperitoneal tissues and small amount to the tissues of extraperitoneal organs.
