Abstract
Three liposoluble platinum complexes, chelate compounds of saturated fatty acids and Cyclohexane-1, 2-diammineplatinum (II)(DACH), have been developed for intra-arterial chemotherapy of the hepatocellular carcinoma using Lipiodol. We studied the anticancer effect of Lipiodol containing these platinum complexes after injection into the hepatic artery of rabbit bearing VX-2 tumor in the liver. The anticancer effect of trans-1-DACH (Myr)2 (DACH C14), leaving group of which was myristic acid, was stronger and more selective than those of the untreated group and the group given Lipiodol alone. The effect depended on content of DACH C14 in Lipiodol. The anticancer effects of trans-1-DACH (Lau)2 (DACH C12) and trans-1-DACH (Dec)2 (DACH C10), leaving groups of which were lauric acid and decanoic acid, respectively, tended to be similar to that of DACH C14. Platinum concentrations in the tumor 7 days after injection into the hepatic artery of rabbits were selectively higher than those in other parts of the liver in all platinum complexes. These results suggest that three liposoluble platinum complexes in Lipiodol are applicable to intra-arterial chemotherapy of hepatocellular carcinoma.
