Antitumor effect of an interleukin 2 mini-pellet on liver metastases of Colon-26 adenocarcinoma in mice

Abstract

The antitumor effect of an interleukin 2 (IL-2) mini-pellet on liver metastases of Colon-26 adenocarcinoma has been evaluated. After the administration of the IL-2 mini-pellet containing I × 10⁶u of IL-2, the serum concentration of IL-2 was detectable for 72 hours. The administration of the IL-2 mini-pellet into the spleen, which was translocated to the subcutaneous position, after the intraportal injection of Colon-26 tumor cells was significantly effective in reducing the number of metastatic nodules and could also prolong the survivals. The lytic activity of splenocytes against YAC-1 cells and Colon-26 cells on day 2 after the administration of the IL-2 mini-pellet were augmented. These findings demonstrated that the IL-2 mini-pellet could be applied to the immunotherapy of hepatic metastases in human.