Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Hepatic targeting of proteins utilizing carbohydrate recognition mechanism
Yoshito Ohtsubo, Jyunko Ohno, Makiya Nishikawa, Takuya Fujita, Mitsuru Hashida, Hitoshi Sezaki
Author information
Keywords: carbohydrate recognition, receptor-mediated endocytosis, hepatic targeting, macromolecules, superoxide dismutase
JOURNAL FREE ACCESS

1991 Volume 6 Issue 1 Pages 13-17

Details
Download PDF (901K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract
Effectiveness of a hepatic targeting system utilizing carbohydrate recognition mechanism was evaluated. Three types of bovine serum albumin (BSA)derivatives with 1-thiogalactoside(Gal-BSA), 1-thioglucoside(Glc-BSA), and 1-thiomannoside (Man-BSA) were synthesized by the amidation method and their disposition characteristics in mice were studied. Gal-BSA and Glc-BSA were rapidly taken up by the liver parenchymal cells, while Man-BSA was accumulated in the non-parenchymal cells due to receptor-mediated endocytosis. Similar results were observed in glycosylated superoxide dismutase and carboxymethyldextran, suggesting wide applicability of this methodology.
Content from these authors
© Japan Society of Drug Delivery System
Previous article Next article
Favorites & Alerts

Recently viewed articles
Share this page
feedback
 Top