Abstract
Prospect for the clinical application of transdermal DDS from the viewpoints of safety, usefulness and effectiveness is described in this review. Development of the more safe materials and improvement of the dosage form itself and package should be required for the popularization of transdermal DDS in the future. Patient compliance instruction is important for getting the better compliance and for a prevention of misuse. Problems of the poor transdermal absorption might be solved by a finding of safe and potent absorption enhancer. Results of our recent studies on enhancing effects and safety of cyclic monoterpenes such as d-limonene are also described.
