Acute toxicity of peplomycin adsorbed on activated carbon particles on subcutaneous adminstration in mice

Abstract

A new dosage format of peplomycin (PEP-CH), which was composed of activated carbon particles adsorbing peplomycin, was tested for its acute toxicity on subcutaneous adminstration in mice, compared with an aqueous peplomycin solution (PEP-SOL). The LD₅₀ value of PEP-CH was 41 mg/kg, and that of PEP-SOL was 27 mg/kg. There were no differences of intoxication symptoms, time of death and body weight change. We concluded that acute toxicity of peplomycin was reduced by using activated carbon particles as a drug carriar.