Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Reviews
Menaquinone as a potential target of antibacterial agents
Atmika PaudelHiroshi HamamotoSuresh PantheeKazuhisa Sekimizu
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2016 Volume 10 Issue 3 Pages 123-128

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Abstract

The current trend of increasing infections by multidrug-resistant pathogens requires the discovery of novel antimicrobial agents with new target and selective toxicity towards pathogens. Menaquinone is a component of electron transport chains in a majority of anaerobic bacteria and Gram-positive bacteria. Due to its exclusivity in bacteria, menaquinone is thought to be a potential target for development of therapeutically effective antibacterial agents without side effects. In this review, we summarize inhibitors of menaquinone biosynthesis and antibiotics directly targeting menaquinone in bacteria.

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© 2016 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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