Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
Original Articles
Clinical effect of long-term administration of tolvaptan in patients with heart failure and chronic kidney disease
Yohei OnoHiroto TakamatsuMasahiro InoueYukio MabuchiTetsuya UedaTadashi SuzukiMasahiko Kurabayashi
Author information

2018 Volume 12 Issue 3 Pages 154-160


The effectiveness of long-term administration of tolvaptan in heart failure (HF) patients with chronic kidney disease (CKD) has not been fully studied. Hence, in this study, we investigated the effects of chronic administration of tolvaptan on patients with HF and CKD. We consecutively enrolled 31 patients with acute HF syndrome (AHFS) who were administrated tolvaptan as a long-term medication (TLV group). All patients had a history of prior HF admission and CKD. We also consecutively enrolled 27 patients with AHFS, a prior history of HF and CKD (conventional group). We compared renal function and outcomes between the two groups at discharge for AHFS and after 6 months of follow-up. The estimate glomerular filtration rate (eGFR) was maintained at approximately the same level in the TLV group exhibited approximately the same eGFR (–1.1 ± 8.3 mL/min/1.73 m2) but decreased in the conventional group (–7.4 ± 10.4 mL/min/1.73 m2). There was a significant difference in the changes observed in eGFR between the conventional and TLV groups (p = 0.01). There were no significant differences in the frequencies of rehospitalization and death. Long-term administration of tolvaptan may prevent increased renal dysfunction in HF patients with CKD. This conclusion should be confirmed in a large-scale prospective study.

Information related to the author
© 2018 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
Previous article Next article