Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Induction of signal transduction pathways related to the pathogenicity of Cryptococcus neoformans in the host environment
Yasuhiko MatsumotoSaki AzamiHaruka ShigaTae NagamachiHikari MoriyamaYuki YamashitaAsami YoshikawaTakashi Sugita
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2019 Volume 13 Issue 4 Pages 177-182


Cryptococcus neoformans, a human pathogenic fungus, infects immunocompromised humans and causes serious diseases such as cerebral meningitis. C. neoformans controls the expression of virulence factors in response to the host environment via various signal transduction pathways. Understanding the molecular mechanisms involved in C. neoformans infection will contribute to the development of methods to prevent and treat C. neoformans-related diseases. C. neoformans produces virulence factors, such as a polysaccharide capsule and melanin, to escape host immunity. Several proteins of C. neoformans are reported to regulate production of the virulence factors. In this review, on the basis of studies using gene-deficient mutants of C. neoformans and animal infection models, we outline the signal transduction pathways involved in the regulation of virulence factors.

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© 2019 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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