Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Original Article
Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons
Shun UtsunomiyaYusuke KishiMasafumi TsuboiDaichi KawaguchiYukiko GotohManabu AbeKenji SakimuraKazuma MaedaHiroshi Takemoto
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2021 Volume 15 Issue 2 Pages 55-65

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Abstract

Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. Together, these results suggest that elevated expression of Ezh1 contributes to maturation of cortical neurons.

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© 2021 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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