Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Pulse corticosteroids for the management of extensive CNS tuberculosis presenting with acute-onset quadriparesis
Umang AroraPrerna GargShrawan Kumar RautDeepti VibhaUpendra BaithaAtin KumarPankaj JorwalManish SonejaAshutosh Biswas
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2022 Volume 16 Issue 2 Pages 102-104


Myelopathy in central nervous system tuberculosis is notorious for poor outcomes, determined by the severity of inflammation and cord level involved. Acute-onset quadriplegia or paraplegia in these cases represents a neuro-emergency. We report a young female with disseminated tuberculosis who presented with acute onset flaccid quadriparesis with loss of bladder and bowel function. Imaging helped identify the extensive involvement of the neuraxis. We propose that, in addition to anti-tubercular therapy, high-dose corticosteroids such as pulse methylprednisolone may result in a meaningful improvement and show greater rapidity of response in cases of severe central nervous system inflammation such as arachnoiditis or myelopathy.

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